![]() Novel targeted agents are currently being investigated in both the upfront and relapse settings, but to date there are few data to suggest durable treatment responses that compare favorably with results of transplantation.Īutologous stem cell transplant Cytarabine High dose Mantle cell lymphoma Rituximab.Ĭopyright © 2017 Elsevier Inc. We argue that consolidative autologous stem cell transplantation in first remission remains the standard of care for the young and fit patient population, based on long-term data from phase II and III trials demonstrating that early transplantation extends both progression-free and overall survival. There are currently few reliable prognostic markers, making it difficult to accurately predict which patients require early intensive treatment. It is a heterogeneous disease, and although most patients experience an aggressive clinical course, some have a more indolent disease and may not require immediate therapy. That said, a number of clinical trials are underway to look at the effectiveness of treatment for these and other conditions. In a child, the decision whether to use cells from the bone marrow or the blood depends on the size of the child.Mantle cell lymphoma is a relatively rare malignancy, comprising fewer than 10% of all non-Hodgkin lymphomas. The FDA has not yet approved stem cell therapy to treat COPD (chronic obstructive pulmonary disease, which includes emphysema and chronic bronchitis), diabetes, stroke, or joint pain caused by arthritis of the knees. In this type of transplant, the patient gets 2 courses of high-dose chemo as myeloablative therapy, each followed by a transplant of their own stem cells. ![]() In adults, most autologous transplants use stem cells from blood. Doing 2 autologous transplants in a row is known as a tandem transplant or a double autologous transplant. This way of collecting stem cells is called apheresis. The machine then returns the remaining blood through a needle in your arm or through a central venous catheter. Your blood is removed from a vein and passed through a machine that separates the stem cells. G-CSF is a protein that is produced naturally in the body. The growth factor G-CSF may be used to stimulate the growth of new stem cells so they spill over into the blood. With PBSCT, the stem cells are taken from your blood.
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